Effects of Carbon Source on the Production of Lovastatin by Aspergillus niger van Tieghem Under Submerge Fermentation

Abstract

This study aimed to determine the effects of the interaction in the production of lovastatin between carbon sources (lactose, honey and glucose as the control) in four different incubation periods (3, 6, 9 and 12 days) with 1% w/v and 2% w/v concentrations. Results showed that honey was the best carbon source in producing an average concentration of 827.11 ± 382.20 μg mL^-1 lovastatin. One percent (w/v) of carbon source produced 1084.00 ± 188.70 μg mL^-1 of lovastatin, which is higher than the one produced at 2% (w/v) (396.30 ± 102.44 μg mL^-1). Highest yield (815.82 ± 469.07 μg mL^-1 ) of lovastatin was obtained on the sixth day of incubation using honey as the carbon source.